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Tetsuo Shiohara Selected Research

Drug Eruptions (Drug Eruption)

11/2018Monocytes are involved in the balance between regulatory T cells and Th17 cells in severe drug eruptions.
1/2012Fixed drug eruption: the dark side of activation of intraepidermal CD8+ T cells uniquely specialized to mediate protective immunity.
9/2009Cytomegalovirus disease during severe drug eruptions: report of 2 cases and retrospective study of 18 patients with drug-induced hypersensitivity syndrome.
6/2009Defective regulatory T cells in patients with severe drug eruptions: timing of the dysfunction is associated with the pathological phenotype and outcome.
1/2009Fixed drug eruption: a prototypic disorder mediated by effector memory T cells.
1/2006Expansion of IL-10-producing CD4+ and CD8+ T cells in fixed drug eruption.
1/2004Successful desensitization to fixed drug eruption: the presence of CD25+CD4+ T cells in the epidermis of fixed drug eruption lesions may be involved in the induction of desensitization.
1/2004Spontaneous tolerance to terbinafine-induced lichenoid drug eruption.
9/2003IFN-gamma-producing effector CD8+ T cells and IL-10-producing regulatory CD4+ T cells in fixed drug eruption.
10/2002Direct evidence for interferon-gamma production by effector-memory-type intraepidermal T cells residing at an effector site of immunopathology in fixed drug eruption.
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Tetsuo Shiohara Research Topics

Disease

30Hypersensitivity (Allergy)
01/2020 - 01/2004
12Drug Hypersensitivity Syndrome
01/2022 - 08/2009
11Drug Eruptions (Drug Eruption)
11/2018 - 08/2002
10Stevens-Johnson Syndrome (Lyell's Syndrome)
01/2016 - 01/2006
8Eosinophilia
01/2022 - 08/2009
8Virus Diseases (Viral Diseases)
02/2018 - 01/2005
6Infections
07/2017 - 07/2005
6Inflammation (Inflammations)
01/2016 - 08/2002
6Skin Diseases (Skin Disease)
01/2009 - 08/2002
4Atopic Dermatitis (Atopic Eczema)
10/2020 - 06/2003
4Drug-Related Side Effects and Adverse Reactions
01/2018 - 03/2011
3Autoimmune Diseases (Autoimmune Disease)
01/2022 - 10/2007
3Bullous Pemphigoid (Pemphigoid)
02/2018 - 01/2002
3Erythema Multiforme
01/2018 - 01/2002
2Mycoplasma Pneumonia
07/2017 - 01/2016
2Contact Dermatitis (Eczema, Contact)
01/2017 - 06/2003
2Dermatitis
06/2014 - 01/2012
2Herpes Zoster
03/2012 - 12/2011
2Ulcer
03/2011 - 09/2009
2Exanthema (Rash)
08/2009 - 05/2009
2Colitis
02/2008 - 02/2007
2Agammaglobulinemia (Hypogammaglobulinemia)
10/2006 - 02/2004
1Pruritus (Itching)
09/2021
1Melanoma (Melanoma, Malignant)
10/2020
1Drug Hypersensitivity (Drug Allergy)
01/2020
1Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis)
02/2019
1Prurigo
01/2019
1Hypohidrosis
01/2019
1Insulinoma
10/2018
1Vitiligo
10/2018
1Uveomeningoencephalitic Syndrome (Vogt Koyanagi Harada Syndrome)
10/2018
1Uveitis
10/2018
1Autoimmune Thyroiditis (Lymphomatous Thyroiditis)
10/2018
1Alopecia (Baldness)
10/2018
1Thyroiditis
10/2018
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
10/2018
1Agranulocytosis (Granulocytopenia)
01/2016
1Lymphadenopathy
06/2013
1Granuloma
06/2013
1Lymphoma (Lymphomas)
06/2013
1Communicable Diseases (Infectious Diseases)
05/2013
1Pneumonia (Pneumonitis)
05/2013
1Herpesviridae Infections (Herpesvirus Infection)
05/2013
1Purpura
01/2013
1Osteonecrosis (Kienbock's Disease)
01/2013
1HIV Infections (HIV Infection)
12/2010
1Lichen Planus (Lichen Ruber Planus)
01/2010
1Leukocytosis (Pleocytosis)
08/2009
1Fever (Fevers)
08/2009
1Lymphocytosis
08/2009
1Rheumatoid Arthritis
01/2008
1Cutaneous Tuberculosis (Scrofuloderma)
01/2008
1Necrosis
08/2007

Drug/Important Bio-Agent (IBA)

46Pharmaceutical PreparationsIBA
01/2022 - 08/2002
9Adrenal Cortex Hormones (Corticosteroids)IBA
01/2019 - 06/2003
6CytokinesIBA
03/2011 - 09/2003
4AntigensIBA
10/2018 - 01/2002
4Anticonvulsants (Antiepileptic Drugs)IBA
01/2018 - 02/2004
4HaptensIBA
01/2017 - 10/2004
3SteroidsIBA
08/2015 - 06/2003
2Antiviral Agents (Antivirals)IBA
01/2020 - 03/2006
2Immunosuppressive Agents (Immunosuppressants)IBA
02/2018 - 12/2010
2Biomarkers (Surrogate Marker)IBA
02/2018 - 09/2013
2Carbamazepine (Tegretol)FDA LinkGeneric
01/2018 - 03/2011
2Immunoglobulin E (IgE)IBA
01/2016 - 06/2014
2LigandsIBA
08/2007 - 09/2005
1GlobulinsIBA
01/2022
1Interleukin-2 (IL2)IBA
01/2022
1Interleukin-4 (Interleukin 4)IBA
01/2022
1Histamine Antagonists (Antihistamines)IBA
09/2021
1Histamine H1 Receptors (Histamine H1 Receptor)IBA
09/2021
1NivolumabIBA
10/2020
1dupilumabIBA
10/2020
1Monoclonal AntibodiesIBA
10/2020
1InterferonsIBA
01/2020
1Clindamycin (Cleocin)FDA LinkGeneric
02/2019
1anti-thyroglobulinIBA
10/2018
1Insulin AntibodiesIBA
10/2018
1Iodide Peroxidase (Deiodinase)IBA
10/2018
1neuromedin UIBA
01/2016
1Immunoglobulins (Immunoglobulin)IBA
08/2015
1MethylprednisoloneFDA LinkGeneric
09/2013
1Aquaporin 5IBA
06/2013
1dermcidinIBA
06/2013
1AutoantibodiesIBA
05/2013
1HLA-A Antigens (HLA-A)IBA
03/2011
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
12/2010
1Prednisolone (Predate)FDA LinkGeneric
12/2010
1Influenza Vaccines (Influenza Vaccine)FDA Link
01/2010
1Valacyclovir (Valtrex)FDA LinkGeneric
07/2009
16-sulfo sialyl Lewis XIBA
03/2008
1FucosyltransferasesIBA
03/2008
1T-Cell Antigen Receptors (T-Cell Receptor)IBA
02/2008
1ChemokinesIBA
02/2008
1Infliximab (Remicade)FDA Link
01/2008
1B-Cell Activating FactorIBA
08/2007
1Transforming Growth Factor beta Receptors (TGF beta Receptors)IBA
08/2007
1Immunoglobulin A (IgA)IBA
08/2007

Therapy/Procedure

8Therapeutics
01/2020 - 05/2002
1Plasmapheresis
03/2011